请教李博士，5％5一氟尿嘧啶软膏治疗BB可以吗？

george007

文章这里有：
崔炳壮用5％5一氟尿嘧啶软膏治疗28例白癜风。每日局部涂药后封包1次，第一日即会出现涂药部位皮肤糜烂，约在7—9天时涂药处皮肤完全糜烂，再经10天随皮肤表面愈合而开始色素沉着。2个月内白斑皮肤可冗全复色。28例中有18例(64％)白斑全部复色，5例(18％)部分复色，5例(18％)无效，没有色素再生。另有报道说，用5％5一氟尿嘧啶软膏治疗白癜风，应先擦伤白斑表皮，然后涂以药膏，之后加以封包，至皮损糜烂时停用。有效患者表现为10天之内表皮新生，其后l～2周色素开始再生，在2个月内所有治疗区域均出现色素再生现象。还有人认为5一氟尿嘧啶软膏治疗对称性肢端型白癜风效果较好。


印度也有人做过类似的：
Dermatol Surg. 2011 Dec;37(12):1763-6. doi: 10.1111/j.1524-4725.2011.02127.x. Epub 2011 Aug 11.
Combination of microdermabrasion and 5-fluorouracil to induce repigmentation in vitiligo: an observational study.
Garg T, Chander R, Jain A.
Source
Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
Abstract
BACKGROUND:
Treatment of resistant vitiligo is challenging. A few well-researched studies have shown variable results with surgical and other therapeutic strategies.
OBJECTIVE:
To evaluate the usefulness of a less-painful method of repigmentation of vitiligo patches.
PATIENTS AND METHODS:
Forty vitiligo patches in 22 c**ecutive patients with resistant vitiligo presenting at a vitiligo clinic of a university teaching medical school in New Delhi, India, were treated with microdermabrasion followed by topical 5% 5-fluorouracil (5-FU).
RESULTS:
One-third of the patches showed more than 50% repigmentation, and one-fourth showed more than 75% repigmentation. Gratifying results were obtained in seven patches after a single session.
CONCLUSION:
Microdermabrasion is adjunctive with topical 5% 5-FU in the treatment of resistant vitiligo patches. Further well-controlled randomized trials are required to validate the observati** of the study. The authors have indicated no significant interest with commercial supporters.
© 2011 by the American Society for Dermatologic Surgery, Inc.
PMID: 21834930 [PubMed - indexed for MEDLINE]


5一氟尿嘧啶 是很多癌症药的成分，才子大哥说很多人化疗后都长了斑，可能就是5一氟尿嘧啶得作用。


大家觉得怎么样？我就担心2点：1：会不会扩散？2：什么副作用？

烟雨之枝

太烈了，不敢用。

babyblue

这个方法太凶残了。。。

股神

可能会把皮肤里其他的有益的东西杀死~导致别的后果。

亦宁

挪到有问必答了，听听李博士意见，个人感觉可行性小！

再见青春

等坐李博士来解答

allon11

等待博士的回答

yuhao

博士说能我才敢用。怕阿。去问问博士吧。

李志强博士

氟尿嘧啶是化疗药物，具有刺激性，作用的道理类似氮芥，但比氮芥温和，有一定效果，但不如传统的激素药膏。

george007

谢谢博士，不知道有没有什么副作用？还有就是会不会造成扩散？