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我也是最近在咱们论坛看见的那则新闻，就是大家一直讨论的芝加哥Loyola大学Caroline Le Poole教授的关于hps70i研究是否可以治愈咱们病的那条新闻。然后我就很感兴趣，于是乎我就用了许多方法最终找到了这个教授的邮箱地址，给她发了将近十封邮件，她今天终于回了。我就问了问研究进程以及最快可以何时应用，虽然不知道到底有没有效果但是有期望总会感觉有支撑。把她的回信附在下边了，感兴趣的可以看一下哦！其实也没有什么很重要的信息，好多新闻中已经提到，不过她有回复他们研究的进度，也就是何时会进行临床试验，我用绿色把那句话标出来了，大家可以看看！再罗嗦一下，虽然没有什么特别有用的信息，但是还是和大家分享一下因为给大家点信心，科技在不断发展，相信咱们的病以后肯定能治愈！！！ Thank you for your email.We are excited about our research to understand the causes and ultimately develop curative measures for your skin disorder. Since I’ve started working on vitiligo more than 20 years ago (my thesis in 1993 was about vitiligo as well) we have gained a lot in understanding why some people develop vitiligo. In this period of time, we’ve been able to identify vitiligo as an autoimmune disease. This means that your immune system mis-identifies your own pigment cells as ‘foreign’ and starts attacking them. We have figured out that it is primarily a specific immune cell, the T cell, that is resp**ible for killing pigment cells, leaving the skin without a source of pigment. We know a lot about what it is that the T cell sees to identify its targets. There have been major attempts to identify hereditary factors in vitiligo, and the genes identified to date support our findings to show that vitiligo is an autoimmune disease. We then wanted to understand why patients develop depigmentation when they do. How does ‘stress’ ultimately translate into an autoimmune resp**e targeting melanocytes? We figured that if this resp**e is funneled through a single molecule, we can possibly block its activity and halt disease development. This is what we set out to do when we initially investigated the role of HSP70 in vitiligo. We then engineered a variant to the molecule that works like an ‘off-switch’ in our mouse models of spontaneous vitiligo. We characterized what happened to immune resp**es in treated animals, and then found that the same changes in immune activation can also be found in (treated) human skin samples.Our recent publication in Science Translational Medicine is the culmination of many years of work, and we hope to continue our research so we will be able to bring our findings to the clinic. If everything is decided in our favor, the earliest we could start a clinical trial to determine the safety of our drug in human patients will be 2 years. In the meantime, we will acquire regulatory approvals, identify sources of support to perform the trials, and test the safety and efficacy of our product in different models. We have already applied for further funding to support this work and our Institution, Loyola, has applied for a patent to cover the technology. We certainly plan to further pursue this and other avenues to treat vitiligo.
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发表于 2013-5-23 20:49:03
楼主
发表于 2013-5-23 21:20:35